Man my allergies kicked up big time, itchy eyes, little athsma, etcc..... The side effect are a nuisance but I charge through them, i will admit my mind is being trouble by another AZ summer on it's way, we are in the 80s and I am not looking forward to the scorching temperatures again. But nothing left to do but complain and bear it and pedal on. Time for new shoes! These fiveten impacts have been strong for 3 years!